Maimonides’ “Guide for the Perplexed” is a work of philosophy, incorporating Neoplatonic, neo-Aristotelian, and Islamic philosophy. Without some knowledge of these topics, it is impossible to understand this book.
One generally studies the Guide after taking classes in classic Greek philosophy (including Socrates, Plato and Aristotle), medieval philosophy, rabbinic Judaism (Mishnah, Midrash, Talmud), and after gaining some knowledge of the Tanakh (Hebrew Bible).
I especially recommend:
Strauss, Leo. “How to Begin Study: The Guide of the Perplexed.” In Pines, S. (tr.) Moses Maimonides, The Guide of the Perplexed. Chicago: The University of Chicago Press
Joel L. Kraemer’s “The Islamic Context of Medieval Jewish Philosophy,” in The Cambridge Companion to Medieval Jewish Philosophy, ed. Daniel H. Frank and Oliver Leaman, 38-68. Cambridge: Cambridge University Press.
“Maimonidean Controversy”, in “Maimonides”, Volume 11 of the Encyclopaedia Judaica, Keter Publishing.
What we need is an expert teacher who has studied this topic for years, such as the Scott Alexander. Presented here are the first chapters of Alexander’s commentary to Maimonides’s Guide.
Part I of the Guide.